Home Contact Us 中文 English
Yourlocation:Home >News> Trimebutine maleate effect on stress-induced changes in gut motility

Trimebutine maleate effect on stress-induced changes in gut motility

Time:2015/9/16 2:14:15

Many reports have described changes in gut motility induced by various kinds of stress,in animals":" and in humans." The effect of Trimebutine maleate on stress-induced changes in gut

motility has been evaluated in animals and,more recently, in humans. In rats, 'travelstress' was induced by a train journey lasting several hours, and intestinal motility was

monitored before and after the journey." Stress induced a significant decrease in the duration of phase III of the MMC (- 30%; P <0.001) lasting up to 48 h after the end of the

journey. Trimebutine maleate (166 ug/kg/h), administered intravenously during the stress,reversed the changes in intestinal motility,while diazepam had no effect on these changes.

In dogs, acoustic stress is known to induce gastric motor inhibitiori." A 1-h acoustic stress, started 40 - 50 min after a gastric MMC, delayed the onset of the next gastric

MMC by 111 %, while the jejunal MMC was not altered." Trimebutine maleate (1 mg/kg, orally) abolished the effect of stress on gastric motility, but had no effect on gastric MMC latency

when administered intravenously or centrally.The antagonistic properties of Trimebutine maleate on stress-induced modifications of gastric motility were inhibited by specific antagonists of K receptors. These results indicate that Trimebutine maleate mainly acts peripherally by inhibiting the effect of stress on gastric motility.

Trimebutine maleate may also act directly on peripheral receptors located in the gut wall.In man, a recent study investigated the influence of Trimebutine maleate on stress-induced changes in jejunal motor activity." Overall,Trimebutine maleate (200 rng, orally, three times daily) reversed the effect of stress on jejunal motility. While fasting, the periodicity of MMC was prolonged under stressful conditions compared with the resting state.232 Trirnebutine, given before stress was applied, corrected the periodicity of MMC to the values observed in the resting state. After a meal,mental stress decreased the contractile amplitude of jejunal contractions compared with postprandial contractile activity under resting conditions. Again, Trimebutine maleate abolished the effects of stress on postprandial contractile activity of the jejunum. By contrast, after Trimebutine maleate, there was no modification

of the frequency of contractions nor of the number of clustered contractions induced by stress."